Холестаза. Клинични, диагностични и терапевтични аспекти View larger

Холестаза. Клинични, диагностични и терапевтични аспекти

2015

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The monograph deals with a significant problem in the gastroenterological clinical practice, the cholestatic syndrome. Cholestatis is defined as impaired bile synthesis, secretion and decreased bile flow into the duodenum. The morphological, functional and etiological classifications are ...

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The monograph deals with a significant problem in the gastroenterological clinical practice, the cholestatic syndrome. Cholestatis is defined as impaired bile synthesis, secretion and decreased bile flow into the duodenum. The morphological, functional and etiological classifications are presented. The author discusses current concepts of pathogenesis and pathophysiological mechanisms of this pathology. The rare inherited forms of cholestasis are comprehensively considered along with total parenteral nutrition-associated, drug-induced and sepsis-related cholestatic injury. The mechanisms of intrahepatic cholestasis of pregnancy, heart-induced liver dysfunction, and jaundice following surgery and liver transplantation are interpreted, too. Particular attention is paid to granulomatous  and infiltrative liver disorders with cholestatic course. Alcoholic and non-alcoholic fatty liver disease presenting with cholestasis as well as acute and chronic viral hepatitis are also described.  Emphasis is made to the classical cholestatic liver diseases such as primary biliary cirrhosis and primary sclerosing cholangitis. An important part of the monograph focuses on the ultrasonographic differential diagnosis of cholestasis.

 

The present monograph illustrates the clinical approach to the cholestatic syndrome as a diagnostic and therapeutic algorithm summarizing the classical and contemporary diagnostic and therapeutic methods. The book reflects the advances in the knowledge about the cholestatic diseases. It addresses a wide range of physicians such as general practitioners, hepatogastroenterologists, pediatricians, liver surgeons, other medical specialists and postgraduate students. Therefore, this treatise provides valuable guidelines for the diagnosis and treatment of cholestasis facing the challenges of the clinical practice. 

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